Intra-arterial papaverine infusions for the treatment of cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage

@article{Liu2005IntraarterialPI,
  title={Intra-arterial papaverine infusions for the treatment of cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage},
  author={James K. Liu and William T. Couldwell},
  journal={Neurocritical Care},
  year={2005},
  volume={2},
  pages={124-132}
}
Cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage that has become refractory to maximal medical management can be treated with selective intra-arterial papaverine infusions. Papaverine is a potent vasodilator of the proximal, intermediate, and distal cerebral arteries and can improve cerebral blood flow (CBF). When infused intra-arterially using endovascular microcatheter techniques, papaverine can effectively increase angiographic vessel diameter, decrease prolonged cerebral… Expand
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Intra-Arterial Nimodipine Infusion for Cerebral Vasospasm in Patients with Aneurysmal Subarachnoid Hemorrhage
  • W. Cho, H. Kang, +6 authors M.H. Han
  • Medicine
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  • 2011
TLDR
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References

SHOWING 1-10 OF 61 REFERENCES
Treatment of cerebral vasospasm with intra-arterial papaverine.
TLDR
In this preliminary anecdotal series of 12 patients who were candidates for balloon angioplasty, vasospasm was treated instead with intra-arterial papaverine, and marked angiographic reversal of the arterial narrowing following papaversine infusion and dramatic reversal of profound neurological deficits were shown. Expand
Intra-arterial papaverine for the treatment of cerebral vasospasm following aneurysmal subarachnoid hemorrhage.
TLDR
Intra-arterial papaverine resulted in reversal of arterial narrowing in the majority of cases, however, this angiographic improvement was associated with cerebral blood flow augmentation in only 46% of cases analyzed, and major clinical improvement in 26%. Expand
Superselective intra-arterial infusion of papaverine for the treatment of cerebral vasospasm after subarachnoid hemorrhage.
TLDR
The successful treatment of cerebral vasospasm after subarachnoid hemorrhage with superselective intra-arterial infusion of papaverine hydrochloride and eight of 10 patients showed improvement in neurological function after the procedure. Expand
Efficacy of multiple intraarterial papaverine infusions for improvement in cerebral circulation time in patients with recurrent cerebral vasospasm.
TLDR
The preliminary results indicate that multiple intraarterial papaverine treatments consistently improve cerebral circulation times, even with repeated infusions in cases of recurrent vasospasm. Expand
Intraarterial papaverine infusion for cerebral vasospasm after subarachnoid hemorrhage.
TLDR
Papaverine was effective in dilating narrowed arteries in most patients with symptomatic vasospasm caused by subarachnoid hemorrhage with encouraging clinical results with no recurrence of neurologic deterioration in those patients who responded well to papaverine. Expand
Intra-arterial papaverine-induced seizures: case report and review of the literature.
TLDR
A patient who developed symptomatic vasospasm after subarachnoid hemorrhage due to rupture of a left terminal internal carotid artery (ICA) saccular aneurysm and recurrent neurologic deficits prompted repeat papaverine administration developed generalized convulsions. Expand
Intracranial pressure changes induced during papaverine infusion for treatment of vasospasm.
TLDR
A careful, titrated infusion of papaverine, with constant reference to the patient's ICP, blood pressure, and pulse rate, minimizes the transient increase in ICP while maintaining adequate blood pressure and CPP. Expand
Paradoxical aggravation of vasospasm with papaverine infusion following aneurysmal subarachnoid hemorrhage. Case report.
TLDR
This is the first clinical case to illustrate a paradoxical effect of intraarterial papaverine treatment for vasospasm following aneurysmal SAH, and possible mechanisms of this paradoxical response and potential therapeutic reactions are reviewed. Expand
Repeat intra-arterial papaverine for recurrent cerebral vasospasm after subarachnoid haemorrhage
TLDR
The preliminary results suggest that repeat papaverine infusion may be a way of controlling recurrent or recalcitrant vasospasm. Expand
Comparison of balloon angioplasty and papaverine infusion for the treatment of vasospasm following aneurysmal subarachnoid hemorrhage
TLDR
Test the hypothesis that balloon angioplasty is superior to papaverine infusion for the treatment of proximal anterior circulation arterial vasospasm following subarachnoid hemorrhage by comparing mean pre- and posttreatment velocity. Expand
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