Intra-arterial infusions of drugs and hyperosmotic solutions as ways of enhancing CNS chemotherapy.

@article{Fenstermacher1981IntraarterialIO,
  title={Intra-arterial infusions of drugs and hyperosmotic solutions as ways of enhancing CNS chemotherapy.},
  author={Joseph D. Fenstermacher and Jurjen Gazendam},
  journal={Cancer treatment reports},
  year={1981},
  volume={65 Suppl 2},
  pages={
          27-37
        }
}
The use of intra-arterial (ia) infusions of drugs to enhance their target tissue uptake and minimize their systemic delivery and toxicity was examined by mathematical analysis and computer modeling. In addition, the effects of intracarotid infusions of hyperosmotic solutions on blood-brain barrier permeability and the transfer of solutes between blood and CNS were evaluated with rats. In virtually all situations, at least some increased target site drug delivery and decreased systemic drug… CONTINUE READING

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