Intra-arterial chemotherapy for retinoblastoma in 70 eyes: outcomes based on the international classification of retinoblastoma.

@article{Shields2014IntraarterialCF,
  title={Intra-arterial chemotherapy for retinoblastoma in 70 eyes: outcomes based on the international classification of retinoblastoma.},
  author={C. Shields and Fairooz P Manjandavida and S. Lally and Giulia Pieretti and Sruthi Arepalli and Emi H. Caywood and P. Jabbour and J. Shields},
  journal={Ophthalmology},
  year={2014},
  volume={121 7},
  pages={
          1453-60
        }
}
OBJECTIVE To analyze our 5-year experience of intra-arterial chemotherapy (IAC) for retinoblastoma as primary or secondary therapy. DESIGN Retrospective interventional case series. PARTICIPANTS A total of 70 eyes of 67 patients. INTERVENTION Ophthalmic artery chemotherapy infusion under fluoroscopic guidance was performed using melphalan (3, 5, or 7.5 mg) in every case, with additional topotecan (1 mg) and/or carboplatin (30 or 50 mg) as necessary. MAIN OUTCOME MEASURES Tumor control… Expand
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Tumor control following intra-arterial chemotherapy (IAC) for retinoblastoma is described and globe salvage was achieved in 8 of 12 eyes treated with primary IAC, including 2 of 2 group C eyes, 4 of 4 group D eyes, and 2 of 6 group E eyes according to the International Classification of Retin Oblastoma. Expand
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The authors' experience suggests that intra-arterial chemotherapy is safe and effective in the treatment of advanced intraocular retinoblastoma. Expand
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One or 2 cycles of IAC can be sufficient for selected eyes with group C or D retinoblastoma, with remarkable tumor control. Expand
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Treatment with IAC for retinoblastoma can lead to mild and severe short-term ocular complications, including eyelid edema as well as potentially blinding vascular obstruction, which should be used with caution. Expand
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Retinoblastoma can be controlled with IAC, but histopathology of enucleated eyes reveals that ocular complications including thromboembolic events can occur. Expand
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Progress has been made in the past few years in the management of retinoblastoma with better enucleation implants, chemoreduction-prevention of pinealoblastomas and excellent tumor control, and the recently popularized modality of intra-arterial chemotherapy is faced with caution and hope. Expand
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