Intra-arterial administration of hexobarbital enantiomers to the rat: disposition and estimation of apparent extraction ratio

@article{Graaff1986IntraarterialAO,
  title={Intra-arterial administration of hexobarbital enantiomers to the rat: disposition and estimation of apparent extraction ratio},
  author={M. Van der Graaff and Nico P E Vermeulen and D. D. Breimer},
  journal={Pharmaceutisch Weekblad},
  year={1986},
  volume={8},
  pages={139-144}
}
The enantiomers of hexobarbital, designated asS(+)-HB andR(−)-HB, were administered intra-arterially to rats in a dose of 25 mg· kg−1. Blood pharmacokinetics of the parent compound and two metabolites as well as urinary excretion of three major metabolites were studied. Using previously obtained data following oral administration ofS(+)-HB andR(−)-HB two different methods for calculation of the hepatic extraction ratio (E) were compared. The metabolite profile in the urine after intra-arterial… CONTINUE READING