Intra-arterial administration of a replication-selective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: a phase I trial

@article{Reid2001IntraarterialAO,
  title={Intra-arterial administration of a replication-selective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: a phase I trial},
  author={Tony Reid and Evanthia C Galanis and James L Abbruzzese and Dan Sze and James Andrews and Larry Romel and Michael Hatfield and Joseph Rubin and David H. Kirn},
  journal={Gene Therapy},
  year={2001},
  volume={8},
  pages={1618-1626}
}
Both replication-incompetent and replication-selective adenoviruses are being developed for the treatment of cancer and other diseases. Concerns have been raised about the safety of intra-vascular adenovirus administration following a patient death on a clinical trial with a replication-defective adenovirus. In addition, the feasibility of vascular delivery to distant tumors has been questioned. dl1520 (ONYX-015) is a replication-selective adenovirus that has previously shown safety and… CONTINUE READING