Intra- and Interspecific Variation in Primate Gene Expression Patterns

@article{Enard2002IntraAI,
  title={Intra- and Interspecific Variation in Primate Gene Expression Patterns},
  author={Wolfgang Enard and Philipp Khaitovich and Joachim Klose and Sebastian Z{\"o}llner and Florian Heissig and Patrick Giavalisco and Kay Nieselt-Struwe and Elaine A. Muchmore and Ajit Varki and Rivka G. Ravid and Gaby G. M. Doxiadis and Ronald Bontrop and Svante P{\"a}{\"a}bo},
  journal={Science},
  year={2002},
  volume={296},
  pages={340 - 343}
}
Although humans and their closest evolutionary relatives, the chimpanzees, are 98.7% identical in their genomic DNA sequences, they differ in many morphological, behavioral, and cognitive aspects. The underlying genetic basis of many of these differences may be altered gene expression. We have compared the transcriptome in blood leukocytes, liver, and brain of humans, chimpanzees, orangutans, and macaques using microarrays, as well as protein expression patterns of humans and chimpanzees using… 
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References

SHOWING 1-10 OF 27 REFERENCES
Genetic differences between humans and great apes.
TLDR
Evaluation of the reported findings indicates that the CMP-sialic hydroxylase mutation is the only one that has so far been shown to result in a global biochemical and structural difference between humans and great apes.
Genomic divergences between humans and other hominoids and the effective population size of the common ancestor of humans and chimpanzees.
TLDR
The human lineage apparently had experienced a large reduction in effective population size after its separation from the chimpanzee lineage, suggesting that the gorilla lineage branched off 1.6 to 2.2 million years earlier than did the human-chimpanzee divergence.
Construction and Analysis of a Human-Chimpanzee Comparative Clone Map
TLDR
A first-generation human-chimpanzee comparative genome map is presented and candidate positions, including two clusters on human chromosome 21 that suggest large, nonrandom regions of difference between the two genomes are detected.
Genetic analysis of the mouse brain proteome
TLDR
8,767 proteins from the mouse brain proteome are resolved by large-gel two-dimensional electrophoresis and 1,324 polymorphic proteins are detected from the European collaborative interspecific backcross, indicating that single proteins may act as polygenic traits.
A chimpanzee genome project is a biomedical imperative.
TLDR
There is clear and compelling biomedical value to giving high priority to the complete sequencing of the chimpanzee genome and that of at least one Old World monkey.
Project normal: Defining normal variance in mouse gene expression
TLDR
The expression levels of several genes varied significantly in more than one tissue, and immune-modulated, stress-induced, and hormonally regulated genes were highly represented among the transcripts that were most variable.
Proteomic comparison of human and great ape blood plasma reveals conserved glycosylation and differences in thyroid hormone metabolism.
TLDR
To explore changes in protein expression and glycosylation that occurred during great ape and human evolution, multiple blood plasma samples from all these species were subjected to high-resolution proteomic analysis.
Genome-wide expression monitoring in Saccharomyces cerevisiae
TLDR
The genomic sequence of the budding yeast Saccharomyces cerevisiae has been used to design and synthesize high-density oligonucleotide arrays for monitoring the expression levels of nearly all yeast genes, and many of the genes observed to be differentially expressed under these conditions are expected, but large differences are also observed.
The human career : human biological and cultural origins
TLDR
Richard G. Klein chronicles the evolution of people from the earliest primates through the emergence of fully modern humans within the past 200,000 years, showing how cumulative discoveries and analyses over the past ten years have significantly refined knowledge of human evolution.
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
TLDR
The neighbor-joining method and Sattath and Tversky's method are shown to be generally better than the other methods for reconstructing phylogenetic trees from evolutionary distance data.
...
...