Intra-amygdala spermidine administration improves inhibitory avoidance performance in rats.

@article{Rubin2001IntraamygdalaSA,
  title={Intra-amygdala spermidine administration improves inhibitory avoidance performance in rats.},
  author={Maribel A Rubin and Juliano A Stiegemeier and M{\'a}rcio A Volkweis and Denise M T Oliveira and Ana C Fenili and Rafael Luis Boemo and Alexandre Jurach and Carlos Fernando Mello},
  journal={European journal of pharmacology},
  year={2001},
  volume={423 1},
  pages={35-9}
}
In the present study, we investigated the effect of immediate post-training bilateral infusion of spermidine, a polyamine agonist, into the amygdala on inhibitory avoidance learning of rats. Bilateral microinjection of spermidine (0.02--20 nmol) caused an increase in test step-down latencies at high concentrations. Administration of arcaine (0.002--0.2 nmol), an antagonist of the NMDA receptor polyamine binding site, decreased test step-down latencies. On the other hand, co-administration of… CONTINUE READING

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