Intra-Organ Variation in Age-Related Mutation Accumulation in the Mouse

  title={Intra-Organ Variation in Age-Related Mutation Accumulation in the Mouse},
  author={Rita A. Busuttil and Ana Mar{\'i}a Reyes Garc{\'i}a and Robert Lee Reddick and Martijn E. T. Doll{\'e} and R. Brent Calder and James F. Nelson and Jan Vijg},
  journal={PLoS ONE},
  pages={431 - 434}
Using a transgenic mouse model harboring chromosomally integrated lacZ mutational target genes, we previously demonstrated that mutations accumulate with age much more rapidly in the small intestine than in the brain. Here it is shown that in the small intestine point mutations preferentially accumulate in epithelial cells of the mucosa scraped off the underlying serosa. The mucosal cells are the differentiated villus cells that have undergone multiple cell divisions. A smaller age-related… CONTINUE READING
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Aging of the genome

  • J Vijg
  • 2007
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