Intra-Golgi protein transport depends on a cholesterol balance in the lipid membrane.

@article{Stven2003IntraGolgiPT,
  title={Intra-Golgi protein transport depends on a cholesterol balance in the lipid membrane.},
  author={Ernstpeter St{\"u}ven and Amir Porat and Frida Shimron and Ephraim Fass and Dora Kaloyanova and Britta Bruegger and Felix Theodor Wieland and Zvulun Elazar and Jeffrey B. Helms},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 52},
  pages={53112-22}
}
Transport of proteins between intracellular membrane compartments is mediated by a protein machinery that regulates the budding and fusion processes of individual transport steps. Although the core proteins of both processes are defined at great detail, much less is known about the involvement of lipids. Here we report that changing the cellular balance of cholesterol resulted in changes of the morphology of the Golgi apparatus, accompanied by an inhibition of protein transport. By using a well… CONTINUE READING