Intra-ER sorting of the peroxisomal membrane protein Pex3 relies on its luminal domain

@inproceedings{Fakieh2013IntraERSO,
  title={Intra-ER sorting of the peroxisomal membrane protein Pex3 relies on its luminal domain},
  author={Mohammad H. Fakieh and Peter J. M. Drake and Joanne Lacey and Joanne M. Munck and Alison M. Motley and Ewald H. Hettema},
  booktitle={Biology open},
  year={2013}
}
Pex3 is an evolutionarily conserved type III peroxisomal membrane protein required for peroxisome formation. It is inserted into the ER membrane and sorted via an ER subdomain (the peroxisomal ER, or pER) to peroxisomes. By constructing chimeras between Pex3 and the type III ER membrane protein Sec66, we have been able to separate the signals that mediate insertion of Pex3 into the ER from those that mediate sorting within the ER to the pER subdomain. The N-terminal 17-amino acid segment of… CONTINUE READING
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