Intra-/inter-laboratory validation study on reactive oxygen species assay for chemical photosafety evaluation using two different solar simulators.

@article{Onoue2014IntrainterlaboratoryVS,
  title={Intra-/inter-laboratory validation study on reactive oxygen species assay for chemical photosafety evaluation using two different solar simulators.},
  author={Satomi Onoue and Kazuhiro Hosoi and Tsuguto Toda and Hironori Takagi and Naoto Osaki and Yasuhiro Matsumoto and Satoru Kawakami and Shinobu Wakuri and Yumiko Iwase and Toshinobu Yamamoto and Kazuichi Nakamura and Yasuo Ohno and Hajime Kojima},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2014},
  volume={28 4},
  pages={515-23}
}
A previous multi-center validation study demonstrated high transferability and reliability of reactive oxygen species (ROS) assay for photosafety evaluation. The present validation study was undertaken to verify further the applicability of different solar simulators and assay performance. In 7 participating laboratories, 2 standards and 42 coded chemicals, including 23 phototoxins and 19 non-phototoxic drugs/chemicals, were assessed by the ROS assay using two different solar simulators (Atlas… CONTINUE READING