Intoxications in the STRIDA project involving a panorama of psychostimulant pyrovalerone derivatives, MDPV copycats

@article{Beck2018IntoxicationsIT,
  title={Intoxications in the STRIDA project involving a panorama of psychostimulant pyrovalerone derivatives, MDPV copycats},
  author={Olof Beck and Matilda B{\"a}ckberg and Patrick Signell and Anders Helander},
  journal={Clinical Toxicology},
  year={2018},
  volume={56},
  pages={256 - 263}
}
Abstract Context: An increasing number of new psychoactive substances (NPS) of different chemical classes have become available through marketing and sale over the Internet. This report from the Swedish STRIDA project presents the prevalence, laboratory results, and clinical features in intoxications involving 11 stimulant pyrovalerone NPS derivatives over a 5-year period. Study design: Case series of consecutive patients with admitted or suspected intake of NPS presenting to Swedish hospitals… 
Acute Intoxications Involving α-Pyrrolidinobutiophenone (α-PBP): Results from the Swedish STRIDA Project
TLDR
Patients with intoxication from α-PBP resembled those by NPS cathinones MDPV andα-PVP, and these patients required monitoring in the intensive care unit of which 8 were graded as severe intoxications.
Occurrence and time course of NPS benzodiazepines in Sweden – results from intoxication cases in the STRIDA project
TLDR
An increasing use of NPS BZD in Sweden was detected in acute intoxication cases, sometimes leading to intensive care monitoring and support needs, and they responded positively to flumazenil treatment.
Blood concentrations of synthetic cathinones
TLDR
Where there is clinical suspicion of death due to synthetic cathinones, postmortem blood concentrations >1 μg/mL (in person without developed tolerance) can be cautiously considered as lethal concentrations, however the exact ranges cannot be established.
A unique case of death by MDPHP with no other co-ingestion: a forensic toxicology case
TLDR
This case report may represent the first case of a fatal acute intoxication caused by MDPHP in a 48-year-old man carried to the A&E department of a big Milanese hospital where he suddenly deceased after brief time.
Comparison of clinical characteristics between meth/amphetamine and synthetic cathinone users presented to the emergency department.
TLDR
It is demonstrated that tachycardia, hyperthermia, and rhabdomyolysis were more common among cathinone users than among meth/amphetamine users presented to EDs.
Synthetic cathinone poisoning from ingestion of drug-laced “instant coffee packets” in Taiwan
TLDR
Patients who report ingesting toxic coffee packets are very likely to have been exposed to synthetic cathinones, and Polysubstance exposure is common following ingestion.
Intoxication cases associated with the novel designer drug 3',4'-Methylenedioxy-α-pyrrolidinohexanophenone (MDPHP) and studies on its human metabolism by high-resolution mass spectrometry.
TLDR
Liquid chromatography high-resolution mass spectrometry was successfully applied to investigate the human in vivo metabolism of MDPHP using authentic human urine samples, and the identified metabolite pattern corroborates the principal metabolic pathways of α-pyrrolidinophenones in humans.
...
1
2
3
4
...

References

SHOWING 1-10 OF 27 REFERENCES
Intoxications involving MDPV in Sweden during 2010–2014: Results from the STRIDA project
TLDR
The main clinical manifestations reported in patients testing positive for MDPV included agitation, tachycardia, and hypertension, which were observed in 130 (67%), 106 (56%), and 65 (34%) cases, respectively, as well as the decline to an almost zero level.
Toxicity evaluation of α-pyrrolidinovalerophenone (α-PVP): results from intoxication cases within the STRIDA project
TLDR
In analytically confirmed α-PVP intoxication cases involving no other stimulant drugs, the urine and serum concentrations showed high variability and the clinical features were consistent with a severe sympathomimetic toxidrome, demonstrating that α- PVP prevailed as a drug of abuse after being classified as a narcotic substance, and despite a high incidence of severe poisonings and fatalities.
Characteristics of analytically confirmed 3-MMC-related intoxications from the Swedish STRIDA project
TLDR
The majority of patients with analytically confirmed 3-MMC exposure had sympathomimetic features similar to those associated with mephedrone intoxication, however, the high incidence of co-exposure to other drugs makes the clinical interpretation difficult.
Detection of new psychoactive substance use among emergency room patients: results from the Swedish STRIDA project.
Identification of novel psychoactive drug use in Sweden based on laboratory analysis – initial experiences from the STRIDA project
TLDR
The initial results of the STRIDA project have documented use of a broad variety of new psychoactive substances among mainly young people all over Sweden.
Use of illicit stimulant drugs in Finland: a wastewater study in ten major cities.
Cytotoxic Activity of Pyrovalerone Derivatives, an Emerging Group of Psychostimulant Designer Cathinones
TLDR
Struckly, the two new generation pyrovalerones seem to be the most potent cytotoxic compounds: both induced highly pronounced mitochondrial dysfunction; the latter also demonstrated significant damage to cell membranes.
Mephedrone related fatalities: a review.
TLDR
Data suggest that the abuse of mephedrone remains to be a public health issue, and mephedrone appears to have a rather narrow therapeutic window that makes its use dangerous.
New Psychoactive Substances (NPS) – the Hydra monster of recreational drugs
TLDR
The Swedish STRIDA project was started in 2010 by the Karolinska Institute and University Laboratory and the Swedish Poisons Information Centre and its main function is to monitor the occurrence and health hazards of NPS in the country.
Multicomponent LC-MS/MS screening method for detection of new psychoactive drugs, legal highs, in urine-experience from the Swedish population.
...
1
2
3
...