Intoxication of Host Cells by the T3SS Phospholipase ExoU: PI(4,5)P2-Associated, Cytoskeletal Collapse and Late Phase Membrane Blebbing

@inproceedings{Sato2014IntoxicationOH,
  title={Intoxication of Host Cells by the T3SS Phospholipase ExoU: PI(4,5)P2-Associated, Cytoskeletal Collapse and Late Phase Membrane Blebbing},
  author={Hiromi Sato and Dara W. Frank},
  booktitle={PloS one},
  year={2014}
}
Pseudomonas aeruginosa is an opportunistic pathogen that is associated with hospital-acquired infections, ventilator-associated pneumonia, and morbidity of immunocompromised individuals. A subpopulation of P. aeruginosa encodes a protein, ExoU, which exhibits acute cytotoxicity. Toxicity is directly related to the phospholipase A2 activity of the protein after injection into the host cytoplasm via a type III secretion system. ExoU enzymatic activity requires eukaryotic cofactors, ubiquitin or… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

Damage repair mechanisms in sensory hair cells

VIEW 2 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 81 REFERENCES

Regulation of the actin cytoskeleton-plasma membrane interplay by phosphoinositides

  • J Saarikangas
  • Physiol Rev
  • 2010
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

The type III secretion injectisome

VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL