Intimal smooth muscle cell proliferation after balloon catheter injury. The role of basic fibroblast growth factor.

@article{Olson1992IntimalSM,
  title={Intimal smooth muscle cell proliferation after balloon catheter injury. The role of basic fibroblast growth factor.},
  author={Nels E. Olson and Sheng-Hao Chao and Volkhard Lindner and Michael A. Reidy},
  journal={The American journal of pathology},
  year={1992},
  volume={140 5},
  pages={1017-23}
}
The localization and synthesis of basic fibroblast growth factor (bFGF) in the rat carotid artery were investigated at times of chronic smooth muscle cell proliferation. Immunocytochemical staining showed the presence of bFGF in the uninjured arterial wall, and after balloon injury, this cellular staining was decreased. Western and northern blot analyses likewise showed that the amount of bFGF protein and mRNA decreased after injury. A neutralizing antibody to bFGF was administered 4 and 5 days… CONTINUE READING