Intestinotrophic effects of exogenous IGF-I are not diminished in IGF binding protein-5 knockout mice.

@article{Murali2007IntestinotrophicEO,
  title={Intestinotrophic effects of exogenous IGF-I are not diminished in IGF binding protein-5 knockout mice.},
  author={Sangita G. Murali and Xiaowen Liu and David W A Nelson and Angela K Hull and Michael F. Grahn and Murray K. Clayton and John E. Pintar and Denise M Ney},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2007},
  volume={292 6},
  pages={R2144-50}
}
IGF binding protein-5 (IGFBP-5) modulates the availability of IGF-I to its receptor and potentiates the intestinotrophic action of IGF-I. Our aim was to test the hypothesis that stimulation of intestinal growth due to coinfusion of IGF-I with total parenteral nutrition (TPN) solution is dependent on increased expression of IGFBP-5 through conducting our studies in IGFBP-5 knockout (KO) mice. IGFBP-5 KO, heterozygote (HT) and wild type (WT) male and female mice were maintained with TPN or TPN… CONTINUE READING