Intestinal villous M cells: an antigen entry site in the mucosal epithelium.

  title={Intestinal villous M cells: an antigen entry site in the mucosal epithelium.},
  author={Myoung Ho Jang and M S Kweon and Koichi Iwatani and Masafumi Yamamoto and Kazutaka Terahara and Chihiro Sasakawa and Toshihiko Suzuki and Tomonori Nochi and Yoshifumi Yokota and Paul D. Rennert and Takachika Hiroi and Hiroshi Tamagawa and Hideki Iijima and Jun Kunisawa and Yoshikazu Yuki and Hiroshi Kiyono},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 16},
M cells located in the follicle-associated epithelium of Peyer's patches (PP) are shown to be the principal sites for the sampling of gut luminal antigens. Thus, PP have long been considered the gatekeepers of the mucosal immune system. Here, we report a distinct gateway for the uptake of gut bacteria: clusters of non-follicle-associated epithelium-associated Ulex europaeus agglutinin (UEA)-1(+) cells, which we have designated intestinal villous M cells. Interestingly, villous M cells are… CONTINUE READING