Intestinal uptake and biliary excretion of the isoflavone genistein in rats.

  title={Intestinal uptake and biliary excretion of the isoflavone genistein in rats.},
  author={Jeffrey N Sfakianos and Lori U Coward and Marion C. Kirk and Stephen Barnes},
  journal={The Journal of nutrition},
  volume={127 7},
The intestinal absorption, biliary excretion and metabolism of genistein, a potent and specific protein tyrosine kinase inhibitor that occurs naturally in soy foods, was examined in anesthetized, adult female rats fitted with indwelling biliary cannulas. 4-14C-Genistein, when infused into the duodenum, was rapidly absorbed from the intestine, taken up by the liver and excreted into the bile as its 7-O-beta-glucuronide conjugate. Cumulative recovery of 14C-radioactivity in the bile over a 4-h… CONTINUE READING


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