Intestinal transporters: enhanced absorption through P-glycoprotein-related drug interactions.

  title={Intestinal transporters: enhanced absorption through P-glycoprotein-related drug interactions.},
  author={Parvin Zakeri-Milani and Hadi Valizadeh},
  journal={Expert opinion on drug metabolism & toxicology},
  volume={10 6},
INTRODUCTION There are many factors that can affect the absorption process of orally administered drugs. Intestinal transporters play an important role in drug absorption. These transporters are divided into two major classes: the solute carriers and the ATP-binding cassette (ABC) transporters. P-glycoprotein (P-gp), belonging to the ABC transporter superfamily, flushes out the substrate drugs from a cell, thus regulating the intestinal absorption of drugs. AREAS COVERED This review gives a… CONTINUE READING
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