Intestinal stem cells protect their genome by selective segregation of template DNA strands.

@article{Potten2002IntestinalSC,
  title={Intestinal stem cells protect their genome by selective segregation of template DNA strands.},
  author={Christopher S. Potten and Gary Owen and Dawn Booth},
  journal={Journal of cell science},
  year={2002},
  volume={115 Pt 11},
  pages={2381-8}
}
The stem cells in the crypts of the small intestinal mucosa divide about a thousand times during the lifespan of a laboratory mouse, and yet they show little evidence of any decline in proliferative potential and rarely develop carcinogenic mutations, suggesting that their genome is extremely well protected. Protection against DNA-replication-induced errors can be achieved by the selective sorting of old (template) and new DNA strands with all template strands retained in the stem cell line… CONTINUE READING
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