Intestinal stem cell function in Drosophila and mice.

  title={Intestinal stem cell function in Drosophila and mice.},
  author={Huaqi Jiang and Bruce A Edgar},
  journal={Current opinion in genetics & development},
  volume={22 4},
Epithelial cells of the digestive tracts of most animals are short-lived, and are constantly replenished by the progeny of long-lived, resident intestinal stem cells. Proper regulation of intestinal stem cell maintenance, proliferation and differentiation is critical for maintaining gut homeostasis. Here we review recent genetic studies of stem cell-mediated homeostatic growth in the Drosophila midgut and the mouse small intestine, highlighting similarities and differences in the mechanisms… CONTINUE READING

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