Intestinal spirochetosis in eight pediatric patients from Southern Sweden.

Abstract

Intestinal spirochetes in humans have been recognized for more than a century, but it is still a matter of debate whether they are just commensal organisms or whether they cause colorectal disease. Most descriptions to date are of adult patients, while reports in the pediatric literature have been scarce. In a retrospective study we found eight children with intestinal spirochetosis. The findings, clinical as well as pathological, with light- and electron microscopy, are presented. In all patients, a 3 microm-thick layer of spirochetes was visualised on the luminal aspect of the epithelial cells covering the enterocytes and part of the gland openings. In five of the eight cases an inflammatory cell reaction was seen by light microscopy and in one patient a picture suggesting intracytoplasmatically located spirochetes was seen by electron microscopy. Despite partial or complete destruction of microvilli, spirochetes were still able to adhere to the enterocyte membranes. In three children there was a clear correlation between treatment and relief of symptoms. In four there was partial improvement and in one child no change in bowel-related symptoms. We believe that intestinal spirochetes may cause colorectal disease in children. Possible pathogenic mechanisms are discussed.

Statistics

0100200'04'06'08'10'12'14'16
Citations per Year

293 Citations

Semantic Scholar estimates that this publication has 293 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Marthinsen2002IntestinalSI, title={Intestinal spirochetosis in eight pediatric patients from Southern Sweden.}, author={Lars M Marthinsen and Roger Will{\'e}n and Birgitta Carl{\'e}n and Eva Lindberg and Gunilla V{\"a}rendh}, journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica}, year={2002}, volume={110 7-8}, pages={571-9} }