Intestinal site-dependent susceptibility to chronic indomethacin in the rat: a morphological and biochemical study.

@article{Nygrd1995IntestinalSS,
  title={Intestinal site-dependent susceptibility to chronic indomethacin in the rat: a morphological and biochemical study.},
  author={Gunhild Nyg{\aa}rd and Andrew Anthony and Khalil Khan and S V Bounds and Jane Caldwell and Amar Paul Dhillon and Roy E. Pounder and A. J. Wakefield},
  journal={Alimentary pharmacology & therapeutics},
  year={1995},
  volume={9 4},
  pages={403-10}
}
BACKGROUND The cyclo-oxygenase inhibitor indomethacin induces a pattern of gastrointestinal injury in the rat that is site-dependent. This study compared the extent of injury to different regions of the rat intestine (small intestine, caecum and colon) with the corresponding changes in arachidonic acid metabolism in these areas, following long-term, low… CONTINUE READING