Intestinal serotonin acts as paracrine substance to mediate pancreatic secretion stimulated by luminal factors.

@article{Li2001IntestinalSA,
  title={Intestinal serotonin acts as paracrine substance to mediate pancreatic secretion stimulated by luminal factors.},
  author={Y. Li and X. Y. Wu and J. X. Zhu and C. Owyang},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2001},
  volume={281 4},
  pages={
          G916-23
        }
}
  • Y. Li, X. Y. Wu, +1 author C. Owyang
  • Published 2001
  • Biology, Medicine
  • American journal of physiology. Gastrointestinal and liver physiology
We recently demonstrated that luminal factors such as osmolality, disaccharides, and mechanical stimulation evoke pancreatic secretion by activating 5-hydroxytryptamine subtype 3 (serotonin-3, 5-HT3) receptors on mucosal vagal afferent fibers in the intestine. We hypothesized that 5-HT released by luminal stimuli acts as a paracrine substance, activating the mucosal vagal afferent fibers to stimulate pancreatic secretion. In the in vivo rat model, luminal perfusion of maltose or hypertonic NaCl… Expand
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