Intestinal secretion is a major route for parent ivermectin elimination in the rat.

@article{Laffont2002IntestinalSI,
  title={Intestinal secretion is a major route for parent ivermectin elimination in the rat.},
  author={C. M. Laffont and Pierre-Louis Toutain and Michel Alvinerie and Alain Bousquet-M{\'e}lou},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2002},
  volume={30 6},
  pages={626-30}
}
The transepithelial intestinal elimination of ivermectin was studied using the intestinal closed-loop model in the rat. The common bile duct was cannulated, and duodenum, jejunum, and ileum were isolated in situ with their intact blood supplies. Following administration of 100, 200, or 400 microg/kg b.wt. ivermectin via the carotid artery, the elimination of parent ivermectin into the small intestinal lumen over 90 min was approximately 5-fold higher than in bile. The major amount of secreted… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 33 references

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

Proceedings of the National Academy of Sciences of the United States of America • 1987
View 4 Excerpts
Highly Influenced

Disposition of ivermectin and cyclosporin A in CF-1 mice deficient in mdr1a P-glycoprotein.

Drug metabolism and disposition: the biological fate of chemicals • 1999
View 3 Excerpts
Highly Influenced

The role of mdr1a P-glycoprotein in the biliary and intestinal secretion of doxorubicin and vinblastine in mice

J Van Asperen, O Van Tellingen, JH Beijnen
Drug Metab Dispos 28:264–267 • 2000
View 3 Excerpts

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