Intestinal receptor for heat-stable enterotoxin of Escherichia coli is tightly coupled to a novel form of particulate guanylate cyclase.

@article{Waldman1986IntestinalRF,
  title={Intestinal receptor for heat-stable enterotoxin of Escherichia coli is tightly coupled to a novel form of particulate guanylate cyclase.},
  author={Scott A. Waldman and T AKAFUMI Kuno and Yoshinori Kamisaki and Ling Yi Chang and Jean Gari{\'e}py and P P O'Hanley and Gary K. Schoolnik and Ferid Murad},
  journal={Infection and immunity},
  year={1986},
  volume={51 1},
  pages={320-6}
}
A novel form of particulate guanylate cyclase tightly coupled by cytoskeletal components to receptors for heat-stable enterotoxin (ST) produced by Escherichia coli can be found in membranes from rat intestinal mucosa. Intestinal particulate guanylate cyclase was resistant to solubilization with detergent alone, with only 30% of the total enzyme activity being extracted with Lubrol-PX. Under similar conditions, 70% of this enzyme was solubilized from rat lung membranes. The addition of high… CONTINUE READING

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