Intestinal physiology and pathology in gene-targeted mouse models of cystic fibrosis.

@article{Grubb1997IntestinalPA,
  title={Intestinal physiology and pathology in gene-targeted mouse models of cystic fibrosis.},
  author={Barbara R. Grubb and Sherif E. Gabriel},
  journal={The American journal of physiology},
  year={1997},
  volume={273 2 Pt 1},
  pages={G258-66}
}
Cystic fibrosis (CF) is a fatal genetic disorder that affects approximately 1 in 2,500 live Caucasian births. The disease can be described as a generalized exocrine disease affecting a variety of epithelial tissues, with early manifestation as meconium ileus in a significant number of neonates. Cloning of the gene causing CF was accomplished in 1989, and the protein product, cystic fibrosis transmembrane conductance regulator (CFTR), has been conclusively shown to be an adenosine 3',5'-cyclic… CONTINUE READING
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