Intestinal phenotype of variable-weight cystic fibrosis knockout mice.

  title={Intestinal phenotype of variable-weight cystic fibrosis knockout mice.},
  author={Juan Carlos Canale-Zambrano and M C Poffenberger and Sean M. Cory and Daryl G Humes and Christina K. Haston},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={293 1},
Cystic fibrosis (CF) transmembrane conductance regulator (Cftr) knockout mice present the clinical features of low body weight and intestinal disease permitting an assessment of the interrelatedness of these phenotypes in a controlled environment. To identify intestinal alterations that are affected by body weight in CF mice, the histological phenotypes of crypt-villus axis height, goblet cell hyperplasia, mast cell infiltrate, crypt cell proliferation, and apoptosis were measured in a… CONTINUE READING