Intestinal permeation and gastrointestinal disease.

  title={Intestinal permeation and gastrointestinal disease.},
  author={Mark Demeo and Ece A. Mutlu and Ali Keshavarzian and Mary Catherine Tobin},
  journal={Journal of clinical gastroenterology},
  volume={34 4},
The gastrointestinal tract constitutes one of the largest sites of exposure to the outside environment. The function of the gastrointestinal tract in monitoring and sealing the host interior from intruders is called the gut barrier. A variety of specific and nonspecific mechanisms are in operation to establish the host barrier; these include luminal mechanisms and digestive enzymes, the epithelial cells together with tight junctions in between them, and the gut immune system. Disruptions in the… CONTINUE READING