Intestinal permeability of sesquiterpenes in the caco-2 cell monolayer model.

  title={Intestinal permeability of sesquiterpenes in the caco-2 cell monolayer model.},
  author={Qi Wu and Bo Zhao and Xiu-wei Yang and Wei Xu and P. Zhang and Lei Zou and Lianxue Zhang},
  journal={Planta medica},
  volume={76 4},
The intestinal permeability of eight sesquiterpenes which are active constituents of some traditional Chinese medicines, were studied by using the Caco-2 cell monolayer; they include tanacetin, artesin, magnolialide, crossostephin, atractylon, isocalamenediol (ICL), bisabolangelone (BSE) and (3 R)-des- O-methyllasiodiplodin (DML). The bidirectional permeability of the eight sesquiterpenes was studied from the apical (AP) side to the basolateral (BL) side or from the BL side to the AP side. The… 

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