• DOI:10.1055/s-0029-1186195
• Corpus ID: 30529140

Intestinal permeability of sesquiterpenes in the caco-2 cell monolayer model.

@article{Wu2010IntestinalPO,
  title={Intestinal permeability of sesquiterpenes in the caco-2 cell monolayer model.},
  author={Qi Wu and Bo Zhao and Xiu-wei Yang and Wei Xu and P. Zhang and Lei Zou and Lianxue Zhang},
  journal={Planta medica},
  year={2010},
  volume={76 4},
  pages={
          319-24
        }
}

• Qi Wu, Bo Zhao, +4 authors Lianxue Zhang
• Published 1 March 2010
• Chemistry
• Planta medica

The intestinal permeability of eight sesquiterpenes which are active constituents of some traditional Chinese medicines, were studied by using the Caco-2 cell monolayer; they include tanacetin, artesin, magnolialide, crossostephin, atractylon, isocalamenediol (ICL), bisabolangelone (BSE) and (3 R)-des- O-methyllasiodiplodin (DML). The bidirectional permeability of the eight sesquiterpenes was studied from the apical (AP) side to the basolateral (BL) side or from the BL side to the AP side. The eight compounds were assayed by HPLC. Transport parameters and apparent permeability coefficients ( P(app)) were then calculated. The bidirectional P(app) values of the eight compounds were compared with those of propranolol, a marker of high permeability and transcellular transport. The transport of the eight sesquiterpenes was concentration-dependent in the range of 10-200 microM. Lower recoveries of ICL, BSE and DML than other sesquiterpenes were found during transport. The results indicated that all the sesquiterpenes are well absorbed mainly by the passive diffusion via the transcellular pathway and metabolism may be involved during the absorption of ICL, BSE and DML.