Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications.

@article{Fasano2012IntestinalPA,
  title={Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications.},
  author={Alessio Fasano},
  journal={Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association},
  year={2012},
  volume={10 10},
  pages={
          1096-100
        }
}
  • Alessio Fasano
  • Published in
    Clinical gastroenterology and…
    2012
  • Biology, Medicine
  • One of the most important and overlooked functions of the gastrointestinal tract is to provide a dynamic barrier to tightly controlled antigen trafficking through both the transcellular and paracellular pathways. Intercellular tight junctions (TJ) are the key structures regulating paracellular trafficking of macromolecules. Although steady progress has been made in understanding TJ ultrastructure, relatively little is known about their pathophysiological regulation. Our discovery of zonulin… CONTINUE READING

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