Intestinal mucosal mast cells in Nippostrongylus-infected mice: lack of sensitivity to corticosteroids.

@article{Newlands1990IntestinalMM,
  title={Intestinal mucosal mast cells in Nippostrongylus-infected mice: lack of sensitivity to corticosteroids.},
  author={George F.J. Newlands and Anne Mackellar and Hugh R. P. Miller},
  journal={International journal for parasitology},
  year={1990},
  volume={20 5},
  pages={669-72}
}
Immune reactions to enteric nematodes, in which mast cells are thought to play an important role, are abrogated following corticosteroid treatment of host animals. This is probably due, at least in part, to inhibition of cytokine production by T cells. It has proved difficult to block worm expulsion in mice with corticosteroids. We have therefore examined the effects of corticosteroids on mast cell numbers and concentrations of the mast cell granule-specific serine protease Mouse Intestinal… CONTINUE READING