Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children

@inproceedings{Korpela2016IntestinalMI,
  title={Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children},
  author={Katri Korpela and Anne Salonen and L J Virta and Riina A. Kekkonen and Kristoffer Forslund and Peer Bork and Willem M de Vos},
  booktitle={Nature communications},
  year={2016}
}
Early-life antibiotic use is associated with increased risk for metabolic and immunological diseases, and mouse studies indicate a causal role of the disrupted microbiome. However, little is known about the impacts of antibiotics on the developing microbiome of children. Here we use phylogenetics, metagenomics and individual antibiotic purchase records to show that macrolide use in 2-7 year-old Finnish children (N=142; sampled at two time points) is associated with a long-lasting shift in… CONTINUE READING
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