Intestinal metabolism of a random-bonded polyglucose bulking agent in humans: in vitro and in vivo studies of hydrogen evolution.


In vivo and in vitro experiments were conducted to determine the extent of intestinal fermentation of polydextrose, a random-bonded glucose polymer proposed as a low-calorie bulking agent in weight-reducing diets. The evolution of hydrogen gas was the index of bacterial fermentation. Oral ingestion of 15 gm polydextrose by healthy volunteers produced a flat… (More)