Intestinal lumen and mucosal microclimate H+ and NH3 concentrations as factors in the etiology of experimental amebiasis.

@article{Leitch1988IntestinalLA,
  title={Intestinal lumen and mucosal microclimate H+ and NH3 concentrations as factors in the etiology of experimental amebiasis.},
  author={Gordon J. Leitch},
  journal={The American journal of tropical medicine and hygiene},
  year={1988},
  volume={38 3},
  pages={480-6}
}
  • Gordon J. Leitch
  • Published 1988 in
    The American journal of tropical medicine and…
Axenically cultivated Entamoeba histolytica, trophozoites, strains HM-1:IMSS and HM-38, were suspended in solutions of NaCl, 330 mOsm, of varying pH and ammonium concentrations. Short-term viability was inversely proportional to the ammonia concentration of the medium and was independent of the ammonium concentration and pH. The NH3-induced ameba killing was associated with a cellular alkalosis and cell swelling. While short-term trophozoite viability was unaffected by changes in the medium pH… CONTINUE READING