Intestinal ischemic preconditioning: Less xanthine accumulation relates with less apoptosis

@article{Sola2004IntestinalIP,
  title={Intestinal ischemic preconditioning: Less xanthine accumulation relates with less apoptosis},
  author={A P{\'e}rez Sola and Vicente Alfaro and Gina Hotter},
  journal={Apoptosis},
  year={2004},
  volume={9},
  pages={353-361}
}
Ischemic preconditioning has shown to reduce apoptosis in the intestinal mucosa during ischemia/reperfusion. This study evaluated if the decrease of apoptotic events found during preconditioning could be related with a reduction of the substrate (i.e., xanthine/hypoxanthine) available for xanthine oxidase (XO). Animals were randomly assigned to the following study groups: C, control; I/R, ischemia/reperfusion; P+I/R, ischemic preconditioning; P+I/R+H/X, ischemic preconditioning plus… CONTINUE READING