Intestinal intraepithelial lymphocytes bind to colon cancer cells by HML-1 and CD11a.

@article{Roberts1993IntestinalIL,
  title={Intestinal intraepithelial lymphocytes bind to colon cancer cells by HML-1 and CD11a.},
  author={Arthur I. Roberts and SEAN M. O'CONNELL and Ellen Catherine Ebert},
  journal={Cancer research},
  year={1993},
  volume={53 7},
  pages={1608-11}
}
Human intraepithelial lymphocytes (IEL), predominantly CD8+ T-lymphocytes located between intestinal epithelial cells (EC), may represent the first-line immune defense against colon cancer. The mechanism by which IEL bind to the colon cancer line, DLD-1, was evaluated. A larger fraction of IEL than peripheral blood mononuclear cells bound to DLD-1 monolayers (25 +/- 16 versus 8 +/- 4% binding, P < 0.05). Binding increased when DLD-1 monolayers were incubated with interferon-gamma but not with… CONTINUE READING
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Integrin aK ß-, mediates adhesion of T lymphocytes to epithelial cells

  • M. B. Brenner
  • J. Immunol.. in press
  • 1993
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