Intestinal inflammation induces adaptation of P-glycoprotein expression and activity.

@article{Buyse2005IntestinalII,
  title={Intestinal inflammation induces adaptation of P-glycoprotein expression and activity.},
  author={Marion Buyse and Genia Radeva and Andr{\'e} Bado and Robert Farinotti},
  journal={Biochemical pharmacology},
  year={2005},
  volume={69 12},
  pages={
          1745-54
        }
}
Recent studies suggest that P-glycoprotein (Pgp) encoded by MDR1 gene, may be an important factor in the pathogenesis of inflammatory bowel disease (IBD). In this study, we investigated intestinal Pgp expression and activity: (1) in IL10 deficient (IL10(-/-)) mice which spontaneously develop intestinal inflammation affecting the small and large intestine and (2) in DSS (dextran sodium sulfate)-induced rat colitis. In IL10(-/-) enterocolitis mice, rhodamine 123 efflux was reduced by two to three… CONTINUE READING
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