Intestinal hydrolysis of aspartylphenylalanine--the metabolic product of aspartame.

Abstract

Aspartame [Nutrasweet, Equal (Searle Consumer Products, Chicago, Ill.)] is the methyl ester of the dipeptide aspartylphenylalanine (Asp-Phe). After hydrolysis of the ester bond in the intestinal lumen, the dipeptide is apparently absorbed and digested in the same manner as dipeptides derived from protein digestion. We observed that Asp-Phe is hydrolyzed… (More)

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