Intestinal homeostasis and its breakdown in inflammatory bowel disease

@article{Maloy2011IntestinalHA,
  title={Intestinal homeostasis and its breakdown in inflammatory bowel disease},
  author={Kevin J. Maloy and Fiona M. Powrie},
  journal={Nature},
  year={2011},
  volume={474},
  pages={298-306}
}
Intestinal homeostasis depends on complex interactions between the microbiota, the intestinal epithelium and the host immune system. Diverse regulatory mechanisms cooperate to maintain intestinal homeostasis, and a breakdown in these pathways may precipitate the chronic inflammatory pathology found in inflammatory bowel disease. It is now evident that immune effector modules that drive intestinal inflammation are conserved across innate and adaptive leukocytes and can be controlled by host… Expand
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