Intestinal heme oxygenase inhibition and increased biliary iron excretion by metalloporphyrins.

Abstract

The effects of synthetic metalloporphyrins on heme oxygenase activity in the epithelium of the proximal region of the small intestine were examined both in vitro and in vivo in male Sprague-Dawley rats. Metalloporphyrins, which inhibit hepatic heme oxygenase in vitro, also inhibit intestinal heme oxygenase. Chromium and tin porphyrins are the most potent… (More)

Topics

Cite this paper

@article{Drummond1992IntestinalHO, title={Intestinal heme oxygenase inhibition and increased biliary iron excretion by metalloporphyrins.}, author={Gabrielle Drummond and Danny Rosenberg and A. Kappas}, journal={Gastroenterology}, year={1992}, volume={102 4 Pt 1}, pages={1170-5} }