Intestinal glutathione: determinant of mucosal peroxide transport, metabolism, and oxidative susceptibility.

@article{Aw2005IntestinalGD,
  title={Intestinal glutathione: determinant of mucosal peroxide transport, metabolism, and oxidative susceptibility.},
  author={Tak Yee Aw},
  journal={Toxicology and applied pharmacology},
  year={2005},
  volume={204 3},
  pages={320-8}
}
  • Tak Yee Aw
  • Published 2005 in Toxicology and applied pharmacology
The intestine is a primary site of nutrient absorption and a critical defense barrier against dietary-derived mutagens, carcinogens, and oxidants. Accumulation of oxidants like peroxidized lipids in the gut lumen can contribute to impairment of mucosal metabolic pathways, enterocyte dysfunction independent of cell injury, and development of gut pathologies, such as inflammation and cancer. Despite this recognition, we know little of the pathways of intestinal transport, metabolism, and luminal… CONTINUE READING

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