Intestinal glutaminase activity is increased in liver cirrhosis and correlates with minimal hepatic encephalopathy.

Abstract

BACKGROUND/AIMS We performed the current study to assess the intestinal activity of enterocyte phosphate-activated glutaminase (PAG) in cirrhosis. METHODS Forty-nine cirrhotic patients and 36 control subjects underwent endoscopic duodenal biopsies. Minimal hepatic encephalopathy (MHE) was evaluated using three psychometric tests. Oral glutamine challenge… (More)

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