Intestinal first-pass metabolism of CYP3A4 substrates.

@article{Kato2008IntestinalFM,
  title={Intestinal first-pass metabolism of CYP3A4 substrates.},
  author={Motohiro Kato},
  journal={Drug metabolism and pharmacokinetics},
  year={2008},
  volume={23 2},
  pages={
          87-94
        }
}
Cytochrome P450 3A4 (CYP3A4) is present not only in the liver but also in the small intestine, where it functions as a barrier against xenobiotics. Some CYP3A4 substrates exhibit low bioavailability due to intestinal first pass metabolism. The AUCs of such CYP3A4 substrates are remarkably changed by the inhibition, induction, and saturation of CYP3A4 and so prediction of intestinal first-pass metabolism is important. In this article, factors affecting intestinal first-pass metabolism of drugs… CONTINUE READING

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