Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing.

@article{Hershberg1997IntestinalEC,
  title={Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing.},
  author={Robert M. Hershberg and Paul E Framson and D H Cho and Lowen Y. Lee and Susan Kovats and Janice Beitz and Janice S Blum and Gerald T Nepom},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={100 1},
  pages={204-15}
}
Intestinal epithelial cells express a low level of HLA class II molecules constitutively, with elevated levels seen in the setting of mucosal inflammation including inflammatory bowel disease. The ability of intestinal epithelial cells to act as antigen presenting cells for alphabeta CD4(+) T lymphocytes was examined through a molecular analysis of the HLA class II antigen processing pathway. We have shown that intestinal epithelial cells contain abundant constitutive levels of the cathepsin… CONTINUE READING