Intestinal epithelial cells secrete exosome-like vesicles.

  title={Intestinal epithelial cells secrete exosome-like vesicles.},
  author={Guillaume van Niel and Graça Raposo and C{\'e}line Candalh and Muriel Boussac and Robert A. Hershberg and Nadine Cerf-Bensussan and Martine Heyman},
  volume={121 2},
BACKGROUND & AIMS Given the observations that intestinal epithelial cells (IECs) can present antigens to CD4(+) T lymphocytes and that professional antigen-presenting cells secrete exosomes (antigen-presenting vesicles), we hypothesized that IECs may secrete exosomes carrying molecules implicated in antigen presentation, which may be able to cross the basement membrane and convey immune information to noncontiguous immune cells. METHODS Human IEC lines HT29-19A and T84-DRB1*0401/CIITA were… CONTINUE READING
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