Intestinal epithelial cells: regulators of barrier function and immune homeostasis

  title={Intestinal epithelial cells: regulators of barrier function and immune homeostasis},
  author={Lance W Peterson and D. Artis},
  journal={Nature Reviews Immunology},
  • Lance W Peterson, D. Artis
  • Published 2014
  • Biology, Medicine
  • Nature Reviews Immunology
  • The abundance of innate and adaptive immune cells that reside together with trillions of beneficial commensal microorganisms in the mammalian gastrointestinal tract requires barrier and regulatory mechanisms that conserve host–microbial interactions and tissue homeostasis. This homeostasis depends on the diverse functions of intestinal epithelial cells (IECs), which include the physical segregation of commensal bacteria and the integration of microbial signals. Hence, IECs are crucial mediators… CONTINUE READING
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