Intestinal epithelial cancer cell anoikis resistance: EGFR-mediated sustained activation of Src overrides Fak-dependent signaling to MEK/Erk and/or PI3-K/Akt-1.

@article{Demers2009IntestinalEC,
  title={Intestinal epithelial cancer cell anoikis resistance: EGFR-mediated sustained activation of Src overrides Fak-dependent signaling to MEK/Erk and/or PI3-K/Akt-1.},
  author={Marie-Jos{\'e}e Demers and Sonya Thibodeau and Dominique No{\"e}l and Naoya Fujita and Takashi Tsuruo and R{\'e}my Gauthier and M{\'e}lina Arguin and Pierre Vachon},
  journal={Journal of cellular biochemistry},
  year={2009},
  volume={107 4},
  pages={639-54}
}
Herein, we investigated the survival roles of Fak, Src, MEK/Erk, and PI3-K/Akt-1 in intestinal epithelial cancer cells (HCT116, HT29, and T84), in comparison to undifferentiated and differentiated intestinal epithelial cells (IECs). We report that: (1) cancer cells display striking anoikis resistance, as opposed to undifferentiated/differentiated IECs; (2) under anoikis conditions and consequent Fak down-activation, cancer cells nevertheless exhibit sustained Fak-Src interactions and Src/MEK… CONTINUE READING