Intestinal epithelial barrier disruption through altered mucosal microRNA expression in human immunodeficiency virus and simian immunodeficiency virus infections.

@article{Gaulke2014IntestinalEB,
  title={Intestinal epithelial barrier disruption through altered mucosal microRNA expression in human immunodeficiency virus and simian immunodeficiency virus infections.},
  author={Christopher A Gaulke and Matthew Porter and Yan-Hong Han and Sumathi Sankaran-Walters and Irina B Grishina and Michael D. George and Angeline Tilly Dang and Shou-Wei Ding and Guochun Jiang and Ian F Korf and Satya Dandekar},
  journal={Journal of virology},
  year={2014},
  volume={88 11},
  pages={
          6268-80
        }
}
UNLABELLED Epithelial barrier dysfunction during human immunodeficiency virus (HIV) infection has largely been attributed to the rapid and severe depletion of CD4(+) T cells in the gastrointestinal (GI) tract. Although it is known that changes in mucosal gene expression contribute to intestinal enteropathy, the role of small noncoding RNAs, specifically microRNA (miRNA), has not been investigated. Using the simian immunodeficiency virus (SIV)-infected nonhuman primate model of HIV pathogenesis… CONTINUE READING

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