Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice

@article{Tanaka2015IntestinalDO,
  title={Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice},
  author={Hiroo Tanaka and Makiko Takechi and Hiroshi Kiyonari and Go Shioi and Atsushi Tamura and Sachiko Tsukita},
  journal={Gut},
  year={2015},
  volume={64},
  pages={1529 - 1538}
}
Objective To design novel anti-inflammation treatments, it is important to recognise two distinct steps of inflammation: initiation and acceleration. In IBDs, intestinal inflammation is reported to be accelerated by dysfunction in the epithelial paracellular barrier formed by tight junctions (TJs). However, it is unclear whether changes in paracellular barrier function initiate inflammation. Some of the intestinal claudin-family proteins, which form the paracellular barrier, show aberrant… 

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