Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8.

@article{Corpe2013IntestinalDA,
  title={Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8.},
  author={Christopher Peter Corpe and Peter Eck and Jin Wang and Hadi Al-Hasani and Mark Levine},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 13},
  pages={9092-101}
}
Intestinal vitamin C (Asc) absorption was believed to be mediated by the Na(+)-dependent ascorbic acid transporter SVCT1. However, Asc transport across the intestines of SVCT1 knock-out mice is normal indicating that alternative ascorbic acid transport mechanisms exist. To investigate these mechanisms, rodents were gavaged with Asc or its oxidized form dehydroascorbic acid (DHA), and plasma Asc concentrations were measured. Asc concentrations doubled following DHA but not Asc gavage. We… CONTINUE READING
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